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Electrospun scaffolds11/6/2023 Graphic abstractĬhronic wounds occur as a result of continuous stimulation of the immune system leading to prolonged tissue inflammation, hence contributing to a delay in wound healing. PLA/C–Ag +S/AL scaffolds have a great potential for use in chronic wounds as well as in tissue and bioengineering applications. They were nontoxic to the cells and provided favorable substrates for the neonatal epidermal keratinocytes cells to undergo cell attachment and proliferation. PLA/C–Ag +S/AL scaffolds and showed antibacterial activity against both gram +ve and gram −ve bacteria. The antimicrobial effect of the scaffolds was evaluated against S. linearis extract to PLA solution culminates in a fiber with the superlative stiffness of 2.1.1 GPa. The elastic modulus of samples revealed that incorporating 1% Ag +S and A. In this study, poly lactic acid (PLA) (20% w/v) and collagen-based (PLA/C) fibrous scaffolds (electrospun at a voltage of 22 kV, flow rate of 0.1 mL/min) containing varying concentrations of silver sulphadiazine (1% w/w, 0.75% w/w) (Ag +S) and Aspalathus linearis (AL) fermented extract (0.025%, 0.1% and 0.5% w/w), were designed and fabricated to increase antimicrobial penetration and cellular biocompatibility. Electrospun biomimetic scaffolds produced from biodegradable polymers have proven to be a better alternative due to their large surface area to volume ratio and ability to release the drug directly to the wound surface allowing fast and sustained absorbance over the affected wound area. Bone, skin and soft tissue chronic wounds emanating from burns or bacterial infections which persist due to prolonged tissue inflammation contribute to a delay in wound healing.
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